Animal Models of Peripheral Neuropathy: Modeling What We Feel, Understanding What They Feel

摘要

Imost everyone has experienced the severe discomfort associated with hitting the “funny bone,''the pushing of the humerus distal medial epicondyle against the ulnar nerve. There is nothing amusing, however, about neuropathic pains and paresthesias that occur chronically, as with peripheral neuropathy. This issue of the Journal details the science of peripheral neuropathy as discovered through animal models. This introduction highlights the clinical description of peripheral neuropathy in order to center on the challenges of constructing animal models.