FORMULATION AND IN VITRO EVALUATION OF GASTRIC FLOATING DRUG DELIVERY SYSTEM FOR CEFPODOXIME PROXETIL BY 3~2TACTORIAL DESIGN

摘要

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing cefpodoxime proxetil as a model drug by the optimization technique. Hydroxypropyl methylcellulose K4M (HPMC K4M) (X_1) and sodium starch glycolate (SSG) (X_2)were used in formulating GFDDS employing 3~2 factorial design. The two dependent variables considered were total floating time (TFT) and time required for cumulative 90% release of drug (t_(90)). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X_1 and X_2 significantly affected the release properties and floating behaviour. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of GFDDS.