A NOVEL APPROACH FOR THE FORMULATION OF GASTRIC ORAL FLOATING DRUG DELIVERY SYSTEM CONTAINING GLIPIZIDE

摘要

Glipizide is an selective second generation sulphonylurea agent used in the treatment of hyperglycaemia. It is a poorly soluble in the acidic environment. When it is given orally in healthy people, it absorbs rapidly and completely. However, the same cannot be said in people with hyperglycaemia problem, as it delays the absorption of glipizide due to impaired gastric emptying or gastric motility. This delay of absorption may be clinically relevant, since the efficacy of short acting sulphenylureas is dependent upon the absorption rate of the drug. To overcome these draw backs, the present study was undertaken to investigate the gastric retentive dosage form of glipizide particularly a floating controlled drug delivery system. Ten formulations containing retardent material and alkalizing agent were prepared with solubilizing agent in different ratio. It was found that sodiumbicarbonate reacts with HCI and produce C02 which creates pores in tablet and elevates swelling by wetting polymer. So it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy and in vitro dissolution studies. Formulation FIO containing HPMC K4 and maximum concentration of sodium bicarbonate and PVP showed better release with therapeutic efficacy in comparison to other formulations.