Solvent-free synthesis of quinazolin-4(3H)-ones pmmoted by SbCl3 under microwave condition

摘要

Efficient and fast condensation of anthranilic amide or anthranilic acid with various acylamides have been carried out using a catalytic amount of Antimony(III) chloride (SbCl3) under microwave irradiation to afford a series of 2-substituted quinazolin-4(3H)-ones in good to excellent yield (65 - 95%) without solvent. The reactions have been carried out without solvent by one-pot reaction in several minutes and optimized. This method shows several advantages of a simple and rapid work-up procedure, a clean conversion, high yields and is environmentally friendly.