Synthesis of some novel chalcones, pyrazolines, aminopyrimidines and their antimicrobial study

摘要

Some new chalcones, 2,4 bis (tetrahydro-1,4-oxazine)-6-[4'-{3"-(substituted phenyl)-2"-propenon-1"-yl} phenyl amino]-s-triazine 6a-f have been achieved by the reaction between 2,4-bis-(tetrahydro-1,4-oxazine)-6-(4'-acetylphenylamino)-s-triazine 5 and different aromatic aldehydes, which on cyclisation with hydrazine hydrate in the presence of acetic acid give acetyl pyrazolines 7a-f. Chalcones 6a-f on cyclisation with guamdine hydrochloride in the presence of alkali give aminopyrimidines 8a-f. The characterization of newly synthesised compounds is based on IR, ~1H NMR spectral data as well as elemental analysis. All the synthesised compounds have been screened for their antimicrobial activity.