Synthesis,spectral studies and biological activity of novel 3H-1,5-benzodiazepine derivatives

摘要

Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one 1 with POCl3 affords 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4,3-d] pyrimidine 2.Further compound 2 is condensed with different beta-diketones / beta-ketoesters3a-e,to obtain new beta-diketones/beta-ketoesters 4a-e.The synthesized new beta-diketones/beta-ketoesters(4a-e)and o-phenylenediamine(o-PDA)gives biologically active 3H-1,5-benzodiazepines 5a-e.All the newly synthesized compounds are characterized by elemental analysis and spectral studies.The compounds 5a-e have been screened for antimicrobial,antifungal and anthelmintic activity.