Synthesis, spectral studies and biological activity of novel 3H-1,5-benzodiazepine derivatives

摘要

Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1, 6-dihydro-7H-pyrazolo [4, 3-d] pyrimidin-7-one I with POCl3 afTords 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4, 3-d] pyrimidine 2. Further compound 2 is condensed with different beta-diketones / beta-ketocsters3a-e, to obtain new beta-diketones/beta-ketoesters 4a-e. The synthesized new beta-diketones/beta-ketoesters (4a-e) and o-phenylenediamine (o-PDA) gives biologically active 3H-1,5-benzodiazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity.