Synthesis of substituted cyclohex-2-enones

摘要

Ethyl acetoacetate reacts with benzylideneacetone, 2-methoxy benzylideneacetone and furfurylideneacetone in the presence of sodium ethoxide as catalyst to yield 4-ethoxycarbonyl-3-methyl-5-phenylcyclohex-2-enone 1a, 4-ethoxycarbonyl-3-methyl-5-(2-methoxyphenyl) cyclohex-2-enone 1b and 4-ethoxycarbonyl-5-(2-furanyl)-3-methylcyclohex-2-enone 1c, respectively. Ethyl benzoylacetate reacts with benzylideneacetone and furfurylideneacetone in the presence of sodium ethoxide to give 4-ethoxycarbonyl-3,5-bis-phenylcyclohex-2-enone 1d and 4-ethoxycarbonyl-5-(2-furanyl)-3-henylcyclohex-2-enone 1e, respectively as products.