Synthesis and electrochemical investigations on 1-[4'-(5',6'-dimethoxypyrimidino-sulphonamoyl)phenylamino]-3-chloro-4,4-diphenylazetidin-2-one

摘要

The electrochemical reduction of 1-[4'-(5",6"-dimethoxypyrimidinosulphonamoyl)phenylamino]-3-chloro-4,4-diphenylazetidin-2-one has been studied over a wide pH range at dropping mercury and glassy carbon electrodes. It gives diffusion-controlled, irreversible and single two-electron wave corresponding to the reduction of -NH-N- moiety. On the basis of polarography, linear sweep and cyclic voltammetry, coulometry, IR and ~1H NMR spectral studies, and product identification, a reaction mechanism is suggested to account for the reduction of these compounds. Kinetic parameters, i.e., charge-transfer coefficient (#alpha#n) and forward rate constant (K~0_(f,h)) have also been calculated.