Chemistry of benzocycloheptenones:part I-Synthesis of 2,5-disubstituted 1,3,4-thiadiazoles/oxadiazoles as biologically active heterocycles

摘要

A series of new 10-methyl-2-(5-methyl/phenyl-1,3,4-thiadiazol-2-ylmethyl) 3,5,6,7-tetrahydro-3H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-thiones 5,8 and 10-methyl-2-(5-methyl/phenyl-1,3,4-oxadiazol-2-ylmethyl)-3,5,6,7-tetrahydro-3H-benzo[6,7] cyclohepta[1,2-c]pyridazin-3-ones 6,9 and other thiadiazole derivatives 11 have been synthesized. All the compounds have been evaluated for their antimicrobial activity.