#alpha#-Dehydro #beta#-amino acid derivatives as turn inducer: Synthesis of potential HIV protease inhib itors based on structural mimicry

摘要

#alpha#-Dehydro #beta#-amino acid derivatives derived di- and tripep-tides 4-7 adopt eight-member turn conformations in CDCl_3 solutions. These peptides show similar hydrogen bonding character-stics as compared to the corresponding L-proline containing peptides 8. Thus the dehydro #beta#-amino acid derived tripeptides 7 may behave as the structural mimic of the L-proline containig tripep-tides 8c which are structural analogues of HIV protease inhibitors