Meta-Analysis: The Relationship Between CTLA-4+49 A/G Polymorphism and Primary Biliary Cirrhosis and Type I Autoimmune Hepatitis

摘要

Objectives: CTLA-4 exon-1 + 49A > G (rs231775) polymorphism has been reported to influence the risk for primary biliary cirrhosis (PBC) as well as type I autoimmune hepatitis (AIH-1) in many studies; however, the results still remain controversial and ambiguous. This study aimed to determine more precise estimations for the relationship between CTLA-4 + 49 A > G polymorphism and the risk for PBC and AIH-1 by using a meta-analysis.