INTERLEUKIN-12 POLYMORPHISMS FOR IDENTIFYING RISK FOR PRIMARY BILIARY CIRRHOSIS

摘要

Primary biliary cirrhosis and related autoimmune disorders are characterized by polymorphisms in various loci including IL-12-related genes, and by reduced levels of IL- 12A transcripts. Methods useful to screen for these defects are described for use in diagnosing these conditions. Methods useful to treat subjects afflicted with these conditions are also described.