Abstract:Three cases with the occurrence of asterixis during the administration of L‐dopa were reported. Liver and metabolic functions were normal in all the patients. Upon the appearance of asterixis no other involuntary movements probably resulting from an excess administration of L‐dopa were observed. Asterixis occurred accompanied by clinical symptoms such as hallucination and a mild clouding of consciousness by insomnia. Because of its reversal with drug withdrawal, asterixis seemed to be L‐dopa‐related. The biochemical basis of asterixis is not known but may involve the dopaminergic or serotonergic
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