Solvent Free Rapid Synthesis of 3-Alkoxycyclohex-2-en-l-one from 1,3-Cyclohexanedione Promoted by Indium(III)Chloride/Silica Gel

摘要

A convenient and environmentally friendly method for the synthesis of 3-alkoxycyclohex-2-en-l-one 1 from cyclohexane-1,3-dione on the surface of silica gel impregnated with indium(III)chloride under microwave irradiation without any solvent has been reported.3-Alkoxycyclohex-2-en-l-ones 1 are of great synthetic interest as they provide synthons for various transformations with extensive applications.Compound 1 is derived from p-cyclohexadione,whose conversion is important for the construction of synthetic intermediates like 4-alkylated cyclohex-2-enones and 3-substituted cyclohex-2-enones.Furthermore,these synthons may act as dienophiles in Diels-Alder reactions.