Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina

摘要

Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC50 value of 59.54 +/- 3.74 mu M.