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The Influence of Levothyroxine on Body Composition and Physical Performance in Subclinical Hypothyroidism

机译:左旋甲状腺素对亚临床甲状腺功能减退症患者身体成分和身体机能的影响

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摘要

Levothyroxine is commonly used to treat hypothyroidism. This study investigates how far the intake of L-T4 influences body composition, energy expenditure, respiratory quotient as well as strength, endurance and mobility in premenopausal women who suffer from subclinical hypothyroidism. Twenty-five women (27.36±5.77 years) with subclinical hypothyroidism were included in the study. The intake of levothyroxine was assumed. Subjects were examined immediately after study inclusion, after two months of levothyroxine use, and after TSH was fully adjusted to the reference range. In all measurements TSH, fT3 and fT4 were determined, body weight, body composition, energy expenditure and the respiratory quotient were measured, and a test battery was performed to identify strength, mobility and endurance capacity. TSH decreased from 5.95±0.99 μIU/ml at study inclusion to 1.2±0.33 μIU/ml after final trial. No change in weight, BMI, muscle mass, fat mass, energy expenditure and respiratory quotient was observed (p>0.05). A significant improvement in chest press (p=0.002), leg extension (p<0.001), right-hand grip strength (p=0.009) shoulder mobility (p<0.001), hip mobility (p=0.07), explosive strength (p=0.041) and the anaerobic threshold (p=0.13) was identified. Likewise, a non-significant (p=0.298) increase in left-hand grip strength could be detected.In summary, although levothyroxine does not positively affect body composition, energy expenditure and respiratory quotient, it can improve strength, mobility and endurance performance. For this reason, treatment with levothyroxine is recommended to improve exercise capacity in subclinical hypothyroidism.
机译:左旋甲状腺素通常用于治疗甲状腺功能减退症。本研究调查了 L-T4 的摄入量对患有亚临床甲状腺功能减退症的绝经前妇女的身体成分、能量消耗、呼吸商以及力量、耐力和活动能力的影响程度。该研究纳入了 25 名患有亚临床甲状腺功能减退症的女性(27.36±5.77 岁)。假设摄入左旋甲状腺素。受试者在纳入研究后、使用左旋甲状腺素两个月后以及 TSH 完全调整到参考范围后立即接受检查。在所有测量中,测定了 TSH、fT3 和 fT4,测量了体重、身体成分、能量消耗和呼吸商,并进行了测试电池以确定力量、活动性和耐力。TSH从纳入研究时的5.95±0.99μIU/ml下降到最终试验后的1.2±0.33μIU/ml。未观察到体重、BMI、肌肉量、脂肪量、能量消耗和呼吸商的变化(p>0.05)。胸部推举 (p=0.002)、腿部伸展 (p<0.001)、右手握力 (p=0.009)、肩部活动度 (p<0.001)、髋关节活动度 (p=0.07)、爆发力 (p=0.041) 和无氧阈值 (p=0.13) 均有显著改善。同样,可以检测到左手握力的非显着 (p=0.298) 增加。综上所述,虽然左旋甲状腺素对身体成分、能量消耗和呼吸商没有积极影响,但它可以提高力量、活动能力和耐力表现。因此,建议使用左旋甲状腺素治疗,以提高亚临床甲状腺功能减退症患者的运动能力。

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