Background: Cefpodoxime has not been reported to cause galactorrhea.Objective: To describe an association between cefpodoxime and galactorrhea.Case Report: A 40-year-old, ambulatory woman reported passage of milk from both breasts for 2 days. She had been taking cefpodoxime, 200 mg twice daily for 4 days, to treat fever and cough. She was not taking any of the drugs or herbs known to cause galactorrhea. She reported no sexual activity in the past 10 days. She reported no visual disturbance or symptoms of increased intracranial pressure. A physical examination revealed no other abnormality. Her fever and cough resolved, but she continued to have galactorrhea. A serum pregnancy test result was negative, and renal function test results and thyroid-stimulating hormone levels were normal. Her serum prolactin concentration was 6854.7 pmol/L (reference values for nonmenopausal women, 625 to 4028.1 pmol/L). A brain magnetic resonance image was normal. Cefpodoxime therapy was stopped. Seven days later, when her serum prolactin level was 1111.2 pmol/L, the breast discharge stopped. One month later, her serum prolactin level decreased even further to 777.84' pmol/L.
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