Ongoing Pursuit of Diterpenoid Alkaloids: A Synthetic View

摘要

The incorporation of nitrogen atoms into policyclic diterpenes has led to one of the most fascinating group of natural products with cage-like structures: diterpenoid alkaloids. Their singular architectural features and significant bioactivities made them highly pursued targets amongst the synthetic community over decades. A total of seven types of diterpenoid alkaloid molecules have been synthesized thus far, and the research in this area experienced a new climax in the past five years. With a brief overview and summary of the historic achievements, this Focus Review particularly covers the recent, post-2010 advances in the field of diterpenoid alkaloid synthesis, highlighting the utilization of innovative synthetic methods and strategies. Despite numerous achievements, there are still a number of such alkaloids with different and unique structural types waiting to be accomplished, implying that the pursuit is far from ending.