Iron-Catalyzed Kumada Cross-Coupling Reactions of Pyrimidin-2-yl Phosphates: An Efficient Approach to C2-Functionalized Pyrimidines

摘要

Iron-catalyzed Kumada cross-coupling reactions of pyrimidin-2-yl phosphates and Grignard reagents are described. The reaction proceeds at room temperature with a short reaction time of 15 minutes, and the corresponding products are obtained with moderate to high yields. A wide array of C2-functionalized pyrimidines has been prepared in moderate to good yields and many functional groups are well tolerated.