Benign tumors from use of oral contraceptive have a greater chance of becoming malignant

摘要

Although very rare, the use of oral contraceptive can lead to benign tumors in the liver. The tumors, known as hepatocellular adenomas, can become malignant. It is, however, difficult for physicians to assess the risk of these tumors becoming malignant. For a study, researchers examined and classified data from 250 patients with hepatocellular adenomas using whole exome sequencing, CGH-SNP analyses, and methylome analyses. They examined classical adenomas, borderline lesions between adenomas and carcinomas and carcinomas.