Spectrophotometric Methods for Simultaneous Estimation of Hydrochlorthiazide and Valsartan

摘要

Two simple,rapid,accurate and precise spectrophotometric methods have been developed for simultaneous estimation of hydrochlorthi-azide and valsartan from tablet dosage form.Method I involves,formation of Q-absorbance equation at 264 nm (isoabsorptive point) and 270.5 (lambda_(max) of hydrochlorthiazide);while method II multicomponent mode of analysis involves the measurement of absorbances at two wavelengths 270.5 (lambda_(max) of hydrochlorthiazide) and 248.5 (lambda_(max) of valsartan) in methanol.The linearity lies between 2-30 mu g/mL for hydrochlorthiazide and 2-80 mu g/mL for valsartan,respectively.The accuracy and precision of the method was determined and validated statistically.The method showed good reproducibility and recovery with RSD % less than 1.The method was found to be rapid,economical,specific,precise and accurate and can be successfully applied for the routine analysis of hydrochlorthiazide and valsartan in bulk and combined dosage form.