Spectrophotometric estimation of metformin hydrochloride in pharmaceutical dosage forms

摘要

Two sensitive and reproducible spectrophotometric methods have been developed for the estimation of metformin hydrochloride in pure and its dosage forms by using 0.1 N NaOH (method A) and pH 7.4 phosphate buffer (method B). The maximum absorbance was observed at 233 nm in both the methods. Beer's law was obeyed in the concentration of 1-30 mug/mL in method A and 1-20 mug/mL in method B.