Evaluation of Antioxidant and Antimicrobial Activities of Drypetes perreticulata Gagnep. Extracts

摘要

The aim of this paper was to screen the petroleum ether, dichloromethane, ethyl acetate and methanol extracts of D. perreticulata leavesand stem. In this study, antioxidant, antimicrobial effects of D. perreticulata leaves and D. perreticulata stem were evaluated using DPPHand FRAP, disc diffusion method, MIC and MTT cytotoxicity assays, respectively. Results showed that petroleum ether, dichloromethane,ethyl acetate, methanol extracts of leaves and stem of D. perreticulata exhibited moderate antioxidant and antibacterial activity. EC_(50),FRAP value of DPSEA were 325.7 μg/mL and 3503.3 ± 63.2 μ mol Fe~(2+)/g in DPPH, FRAP method, respectively. All the extracts showedno inhibitory effect on tested fungi strain, Candida albicans. The petroleum ether extracts exhibited a broad spectrum cytotoxicityactivity, in which IC_(50) were frofn 76.79 to 682.5 ug/mL. Results demonstrated that the extracts prepared from D. perreticulata possessantioxidant activity in vitro and antibacterial properties. It is concluded that the D. perreticulata extracts can be useful as a naturalantioxidant and a probable antibacterial agent.