Electrochemical Determination of Ranitidine Hydrochloride in Pharmaceutical Formulations and Biological Fluids at Graphene Modified Electrode

摘要

A simple and sensitive method is described for electrochemical determination of ranitidine hydrochloride, a widely used histamine H2-receptor antagonist, based on its electrochemical oxidation at a graphene modified glassy carbon electrode (GCE), Under optimized conditions, the anodic peak current was linear to the concentration of ranitidine hydrochloride in the range from 3.0 x 10~(-7)-1.0 x 10~(-4) mol/L with the detection limit of 1.0 x 10~(-7) mol/L. The relative standard deviation (RSD) was 2.6 % for 2.0 x 10~(-5) mol/L ranitidine hydrochloride (n = 10). To further validate its possible application, the proposed method was successfully used for the determination of ranitidine hydrochloride in pharmaceutical formulations and biological fluids with satisfactory results.