Synthesis and Biological Evaluation of 3-Amino Pyrazolones

摘要

A series of 3-amino-4-(substituted benzylidene)-1H-pyrazol-5(4H)-ones were synthesized by condensation of ethyl-2-cyano-3-(substi-tuted) phenylacrylates with hydrazine hydrate. The chemical structures of synthesized compounds were confirmed by means of IR, ~1H NMR, mass spectral and elemental analysis. All the compounds were screened for their antiinflammatory, analgesic and antioxidant activities. Out of these compounds, 4-hydroxy-3,5-dimethoxy (24) and 4-dimethylamino (17) derivatives showed good antiinflammatory activity. 4-dimethylamino (17) and 5-bromo-4-hydroxy-3-methoxy (23) derivatives showed moderate analgesic activity.