Synthesis of 3-Chloro-1-(2-chlbro-1,8-naphthyridin-7-yl)-4-arylazetidin-2-ones and 3-(2-Chloro-1,8-naphthyridine-7-yl)-2-arylthiazoIidin-4-ones From 2-Amino-7-chloro-1,8-naphthyridine

摘要

2-Amino-7-chloro-1,8-napthyridine(1)undergoes condensation with different aromatic aldehydes to form 2-arylideneamino-7-chloro-1,8-naphthyridines(2-6).These imines when treated with different reagents varied substituted derivatives are produced.Compounds 2-6 are converted to different dyes(7-11)by diazotization.Azetidinones(12-16)are obtained by the reaction of 2-6 and chloroacetylchloride in presence of triethylamine.Finally the imines are converted to thiazolidinones(17-21)by treating compounds with thioglycolic acid.