Arsenic is a human carcinogen known to induce tumors of the urinary bladder, skin, liver and lung (Dopp et al. 2009; Beyersmann and Hartwig 2008). Genotoxicity of arsenic is not caused by direct interaction with DNA but by indirect processes, including generation of reactive oxygen species and inhibition of DNA repair processes. Drinking water represents a common source of human exposure. Tens of millions of humans in Southeast Asia routinely drink ground water with too high arsenic concentrations (Polizzotto et al. 2008). Recently, indoor combustion of high arsenic-containing coal has been reported to contribute to human exposure (Chen et al. 2007a, b, 2009; Masoudi and Saadat 2008; Lin et al. 2007).
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