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In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
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机译:评估异种生物作为人体肝细胞中药物运输和代谢免疫调节剂的体外测试系统
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摘要
A kit and method for evaluating in vitro the effect of a xenobiotic (e.g., a biologic drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
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