A case report of daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) as an adjunctive treatment for Alzheimer disease

摘要

Alzheimer's disease (AD) is the most common type of dementia. Current medication treatment is based on two main groups: anticholinesterases (IAChE) and NMDA receptor antagonists. These medications have demonstrated a symptomatic effect on certain cognitive and noncognitive symptoms of AD in the short term (6 months in most studies), although these effects are only limited.1'2 With diagnostic tools for AD becoming increasingly sophisticated, the pathology is identified at earlier stages than before,3 so suitable therapies must follow to limit the progression of the illness and the cognitive loss associated with it. We report the use of a noninvasive procedure, repetitive transcranial magnetic stimulation (rTMS), on cognitive symptoms of an AD patient.