Alcohol Intoxication by Binge Drinking Impairs Neuroplasticity

摘要

Background: Binge drinking, resulting in acute alcohol intoxication, is considered an initial step in developing alcohol use disorders (AUDs). It has been suggested that alcohol intoxication may act on mechanisms of neuroplasticity to produce brain changes that contribute to the pathophysiology of AUDs. However, the effect of binge drinking on neuroplasticity has not been evaluated in humans. Objective: The current study was aimed at evaluating the effect of a binge drinking episode on LTP-like neuroplasticity.