Palindromic rheumatism (PR) is an episodic arthropathy characterised by recurrent attacks of short-lasting articular and periarticular inflammation without residual joint involvement. Although definite knowledge on the disease entity of PR is lacking, the clinical and immunological similarities and the frequent progression to chronic arthritis may suggest a pathogenic relationship with rheumatoid arthritis (RA).1 2 In particular, anticitrullinated protein antibody (ACPA)-positive PR has been regarded as a prodromic phase of RA.3 Compared with autoantibody-positive arthralgia, a well-established model of preclinical RA,4 ACPA-positive PR shows a clearly detectable articular phase and might thus represent a very early self-remitting stage of the disease.
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