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Age dependence of the renal apparent diffusion coefficient in children.

机译:儿童肾脏表观扩散系数的年龄依赖性。

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BACKGROUND: Diffusion imaging has proved to be a powerful tool for diagnosing ischemic lesions in the brain, and the technique is now being applied to other organs, including the kidneys. For quantitative studies it is important to define the normal values of the apparent diffusion coefficient (ADC), given the important physiological changes that occur in the kidney during early childhood it is likely that the ADC changes markedly during this period. OBJECTIVE. To evaluate the age dependent changes in the ADC of normal kidneys in the pediatric population. MATERIALS AND METHODS: The whole kidney ADC was calculated for 62 pediatric patients on a 1.5-T system using a respiratory-triggered, single-shot diffusion tensor imaging sequence with b values of 50, 200, and 350 mm(2)/s. RESULTS. The ADC was found to increase with age with the largest increase being in the first year of life, the rate of change being described by a constant plus a power function, specifically 1349+358.5*age 0.34, ( P<0.001). CONCLUSION: The renal ADC changes significantly during childhood.
机译:背景:弥散成像已被证明是诊断大脑缺血性病变的有力工具,该技术现在正应用于其他器官,包括肾脏。对于定量研究,定义表观扩散系数 (ADC) 的正常值很重要,鉴于儿童早期肾脏发生的重要生理变化,在此期间 ADC 可能会发生显着变化。目的。评估儿科人群中正常肾脏ADC的年龄依赖性变化。材料和方法: 使用 b 值为 50、200 和 350 mm(2)/s 的呼吸触发单次弥散张量成像序列,在 1.5-T 系统上计算 62 例儿科患者的全肾 ADC。研究发现ADC随着年龄的增长而增加,最大的增加是在出生后的第一年,变化率由常数加幂函数描述,特别是1349+[358.5*[年龄0.34]],(P<0.001)。结论:肾脏ADC在儿童期有显著变化。

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