HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: A multidrug hypersensitivity marker?

摘要

Methotrexate-induced interstitial lung disease (MI-ILD) can occur in rheumatoid arthritis (RA) patients. It is believed that Japanese RA patients are more susceptible to MI-ILD than other ethnic groups, suggesting that genetic factors are involved in the pathogenesis of MI-ILD. To date, biomarkers to predict development of MI-ILD in RA have not been established. A striking association between human leukocyte antigen (HLA) class I and cutaneous adverse reactions has been reported for several drugs. Here, we investigated HLA class I associations with MI-ILD in Japanese RA patients.