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Residual image registration error by fiducial markers in accelerated partial breast irradiation using C?arm linac: a phantom study

机译:使用 C?arm 直线加速器加速部分乳腺照射中基准标记的残余图像配准误差:一项模型研究

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摘要

External beam accelerated partial breast irradiation (APBI) is an alternative treatment for patients with early-stage breastcancer. The efficacy of image-guided radiotherapy (IGRT) using fiducial markers, such as gold markers or surgical clips, hasbeen demonstrated. However, the effects of respiratory motion during a single fraction have not been reported. This studyaimed to evaluate the residual image registration error of fiducial marker-based IGRT by respiratory motion and propose asuitable treatment strategy. We developed an acrylic phantom embedded with surgical clips to verify the registration errorunder moving conditions. The frequency of the phase difference in the respiratory cycle due to sequential acquisition wasverified in a preliminary study. Fiducial marker-based IGRT was then performed in ten scenarios. The residual registrationerror (RRE) was calculated on the basis of the differences in the coordinates of clips between the true position if not movedand the last position. The frequencies of the phase differences in 0.0–0.99, 1.0–1.99, 2.0–2.99, 3.0–3.99, and 4.0–5.0 mmwere 23, 24, 22, 20, and 11, respectively. When assuming a clinical case, the mean RREs for all directions werewithin 1.0 mm, even if respiratory motion of 5 mm existed in two axes. For APBI with fiducial marker-based IGRT, theintroduction of an image registration strategy that employs stepwise couch correction using at least three orthogonal imagesshould be considered.
机译:体外加速部分乳房辐照(APBI)是一种替代治疗对早期乳腺癌患者图像引导放射治疗(IGRT)的效果使用基准标记,标记或如黄金手术视频,在一个单一的呼吸运动的影响分数还没有被报道。评估剩余图像配准误差以基准标记为准的IGRT的呼吸运动和提出一个我们开发了一个丙烯酸幻影嵌入手术视频验证登记错误由于相位差的呼吸循环连续采集是初步研究。然后在十个场景中执行。登记基础的坐标的差异如果不是感动片段之间的真正位置最后一个位置。3.0 - -3.99, 4.0 - -5.0毫米和11%,分别。情况下,意味着对各个方向的rr是5毫米中存在两个轴。概略介绍IGRT,注册策略,采用逐步沙发上使用至少三个正交校正图片

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