Quality of local treatment or biology of the tumor: Which are the trump cards for loco-regional control of retroperitoneal sarcoma?

摘要

Surgery remains the mainstay of curative therapy for retroperitoneal sarcoma (RPS). Local control is critical to achieve this objective, yet is not possible to achieve even initially in as many as 50 % of patients. Unlike sarcoma arising at other sites, anatomical constraints in the retro-peritoneum limit the ability to achieve wide resection margins. As a consequence, local recurrences in RPS are more frequent than in extremity sarcoma and comprise the leading cause of death especially for low-to-intermediate grade tumors, e.g., liposarcoma, the histopathological subtype of approximately one-half of sarcomas arising at this site.