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Telomere length predicts neutrophil recovery in the absence of G-CSF after autologous peripheral blood stem cell transplantation.

机译:自体外周血干细胞移植后,端粒长度预测在缺乏G-CSF的情况下中性粒细胞的恢复。

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Summary:Haemopoietic regeneration after autologous peripheral blood progenitor cell (PBPC) transplantation can be delayed in some patients despite adequate infusion of CD34(+) cells. This suggests variability in the proliferation potential of the implanted cells, a capacity that may be predicted by their telomere length. To test this theory, telomere length was measured on stored apheresis samples from 36 patients aged 46.6+/-11.1 years, who had undergone successful autologous PBPC transplantation with a median of 5.6 x 10(6)/kg (1.3 x 10(6)-36.1 x 10(6)/kg) CD34(+) cells. The mean PBPC telomere length for the cohort was 9.4+/-2.3 kbp. For patients who did not receive G-CSF post transplantation (n=7), days to absolute neutrophil recovery (ANC), >/=0.1, 0.5 and 1.0 x 10(9) cells/l, were significantly inversely correlated with telomere length of the infused PBPC (r=-0.88, -0.81, -0.77, respectively; P<0.05,). However, no correlation was found for patients who received G-CSF from day 1 post transplantation (n=20). These data suggest that for transplantation with sufficient CD34(+) cells, neutrophil recovery is less efficient in patients receiving infusions of cells with short telomeres, but this deficiency can be corrected with adequate post transplantation administration of G-CSF.Bone Marrow Transplantation (2004) 34, 439-445. doi:10.1038/sj.bmt.1704607 Published online 19 July 2004
机译:摘要:尽管充分注入了CD34(+)细胞,但某些患者自体外周血祖细胞(PBPC)移植后的造血再生可能会延迟。这暗示了植入细胞的增殖潜能的可变性,其容量可以通过其端粒长度来预测。为了验证这一理论,我们从36位年龄在46.6 +/- 11.1岁的患者中收集了单采血液样本,测量了端粒长度,这些患者已经成功进行了自体PBPC移植,中位值为5.6 x 10(6)/ kg(1.3 x 10(6)) -36.1 x 10(6)/ kg)CD34(+)细胞。该队列的平均PBPC端粒长度为9.4 +/- 2.3 kbp。对于移植后未接受G-CSF的患者(n = 7),中性粒细胞绝对恢复(ANC)的天数> / = 0.1、0.5和1.0 x 10(9)细胞/ l与端粒长度显着负相关注入的PBPC的最大剂量(分别为r = -0.88,-0.81,-0.77; P <0.05)。但是,从移植后第1天开始接受G-CSF的患者中未发现相关性(n = 20)。这些数据表明,对于具有足够CD34(+)细胞的移植,接受短端粒细胞输注的患者中性粒细胞的恢复效率较低,但是可以通过在G-CSF移植后给予适当的治疗来纠正这种缺陷.2004年,骨髓移植)34,439-445。 doi:10.1038 / sj.bmt.1704607 2004年7月19日在线发布

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