Impact of Race on Intraoperative Parathyroid Hormone Kinetics-An Analysis of 910 Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

摘要

African American patients exhibit different intraoperative parathyroid hormone (IOPTH) profiles than non-African American patients. Retrospective review. University medical center. Nine hundred ten patients who underwent parathyroidectomy for primary hyperparathyroidism between July 2005 and August 2010. All patients underwent preoperative imaging with ultrasoriography and sestantibi; operative exploration; and IOPTH measurement at 2 points pre-excision and 5 and 10 minutes postexcision. Preexcision and postexcision IOPTH measurements. Of the 910 patients, 734 self-reported their race as white (81%); 91, Latino/other (10%); 56, Asian (6%); and 28, African American (3%). African American patients had significantly higher initial preexcision IOPTH levels compared with white patients (348 vs 202 pg/mL; P=.048) and significantly higher 5-minute postexcision IOPTH levels (151 vs 80 pg/mL; P=.01). The 10-minute postexcision IOPTH levels were similar between the 2 groups (52 vs 50 pg/mL). A similar percentage of white and African American patients had a 50% drop in IOPTH level at 10 minutes postexcision. No differences in IOPTH kinetics were observed in the other racial groups examined. Conclusions: African American patients with primary hyperparathyroidism exhibit significantly higher prein-cision and 5-minute postexcision IOPTH values when compared with white patients. The 10-minute postexcision IOPTH values did not differ between races. The altered IOPTH kinetics identified in African American patients may reflect the severity of biochemical disease but may also be related to genetically predetermined differences in parathyroid hormone metabolism.