Use of captopril in paediatric congestive cardiac failure: Early effects on blood pressure and renal function

摘要

These animal models have been vitally important in generating and testing hypotheses. However, there are important differences between these models and human SUDEP; for example, if not resuscitated, some animal models (e.g., DBA/2 mice) die nearly every time they have a generalized seizure (9). In contrast, some epilepsy patients who die of SUDEP might have hundreds of seizures pass uneventfully before a fatal event. It will be important to determine whether differences between animal models and human SUDEP point to different underlying mechanisms so that we learn how data from animals can be translated to humans.