What is optimal timing misoprostol for cervical priming prior to first-trimester surgical abortion?

摘要

Our objective was to compare the effectiveness of the misoprostol two and six hours before first trimester surgical abortion for cervical priming. MATERIALS AND METHOD: In a randomized placebo controlled triai, 90 primigravid women who were undergoing surgical abortion were assigned randomly two and six hours before to receive misoprostol (400 mu g) by vaginal route. Three groups of 90 women were randomly assigned to receive either placebo (control group) or vaginal misoprostol in doses of 400p.g 2 h (groupl) or 4 h (group 2) before the surgical procedure. The primary outcome measure was cervical canal width, assessed by the largest size of Hegar dilator that could be inserted without resistance. The secondary outcomes were complications as well as adverse effects.