Chiral Resolution of Some Piperidine 2, 6-dione Drugs by High Performance Liquid Chromatography on Kromasil(R) CHI-DMB Column.

摘要

Kromasil(R) CHI-DMB chiral stationary phase (CSP) is used to resolve some piperidine-2, 6-diones under normal mobile phase mode. Base-line separation was achieved using hexane and dioxane (90 : 10 v/v) for aminoglutethimide (AG), pyridoglutethimide (PG), cyclohexylaminoglutethimide (ChAG), thioglutethimide (TG), and N-acetyl aminoglutethimide (AAG). The chromatographic parameters are reported. The chiral recognition mechanisms between the analytes and the CSP depend primarily on hydrogen bonding and/or (pi-pi) interactions.