Copper(II)-Catalyzed Aerobic Oxidative Coupling between Chalcone and 2-Aminopyridine via C—H Amination: An Expedient Synthesis of 3-Aroylimidazo[1,2-a]pyridines

摘要

A simple and efficient protocol has been developed for the synthesis of 3-aroylimidazopyri-dines via copper(II) acetate-catalyzed aerobic oxidative amination. A library of 3-aroylimidazopyri-dines was synthesized from readily accessible chal-cones and 2-aminopyridines with high yields and re-gioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.