Gold(I)-Catalyzed Regio- and Stereoselective 1,3-Dipolar Cycloaddition Reactions of l-(l-Alkynyl)cyclopropyl Oximes with Nitrones: A Modular Entry to Highly Substituted Pyrrolo[3,4-d] [l,2]oxazepines

摘要

An efficient approach for the synthesis of highly substituted pyrrolo[3,4-d][l,2]oxazepines has been achieved by gold(I)-catalyzed 1,3-dipolar cycloaddition reactions of l-(l-alkynyl)cyclopropyl oximes with nitrones in good to excellent yields as a single diastereomer. A complete chirality transfer was observed in this transformation.