Regioselective Copper(II)-Mediated Bromoamination of Unfunctionalized Olefins: An Efficient Route to N-Heterocyclic Compounds

摘要

Bromoaminatibn of unfunctionalized olefins was realized under mild conditions using cop-per(II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biologically important structures could be obtained via subsequent nucleophilic substitution reactions.