首页> 外文期刊>Neurology: Official Journal of the American Academy of Neurology >Occupational exposure to pesticides increases the risk of incident AD: the Cache County study.
【24h】

Occupational exposure to pesticides increases the risk of incident AD: the Cache County study.

机译:职业接触杀虫剂就增加了广告的风险事件:缓存县研究。

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

BACKGROUND: Commonly used organophosphate and organochlorine pesticides inhibit acetylcholinesterase at synapses in the somatic, autonomic, and central nervous systems and may therefore have lasting effects on the nervous system. Few studies have examined the relationship of pesticide exposure and risk of dementia or Alzheimer disease (AD). We sought to examine the association of occupational pesticide exposure and the risk of incident dementia and AD in later life. METHODS: Residents of the agricultural community of Cache County, UT, who were aged 65 years and older as of January 1995, were invited to participate in the study. At baseline, participants completed detailed occupational history questionnaires that included information about exposures to various types of pesticides. Cognitive status was assessed at baseline and after 3, 7, and 10 years. Standardized methods were used for detection and diagnosis of dementia and AD. Cox proportional hazards survival analyses were used to evaluate the risk of incident dementia and AD associated with pesticide exposure. RESULTS: Among 3,084 enrollees without dementia, more men than women reported pesticide exposure (p < 0.0001). Exposed individuals (n = 572) had more years of education (p < 0.01) but did not differ from others in age. Some 500 individuals developed incident dementia, 344 with AD. After adjustment for baseline age, sex, education, APOE epsilon4 status, and baseline Modified Mini-Mental State Examination scores, Cox proportional hazards models showed increased risks among pesticide-exposed individuals for all-cause dementia, with hazard ratio (HR) 1.38 and 95% confidence interval (CI) 1.09-1.76, and for AD (HR 1.42, 95% CI 1.06-1.91). The risk of AD associated with organophosphate exposure (HR 1.53, 95% CI 1.05-2.23) was slightly higher than the risk associated with organochlorines (HR 1.49, 95% CI 0.99-2.24), which was nearly significant. CONCLUSIONS: Pesticide exposure may increase the risk of dementia and Alzheimer disease in late life.
机译:背景:常用的有机磷和有机氯农药抑制乙酰胆碱酯酶在突触体,自主,中枢神经系统和可能因此对神经有持久的影响系统。农药暴露和风险的关系痴呆和阿尔茨海默病(AD)。检查职业协会的农药暴露和风险事件痴呆和广告在以后的生活。缓存县的农业社区,UT年龄在65岁及以上的1995年1月,被邀请参加这项研究。基线,参与者完成了详细的职业的调查问卷,其中包括历史接触各种类型的信息农药。基线和后3、7和10年。被用于检测和标准化的方法诊断为痴呆和广告。生存分析是用来评估风险事件痴呆和广告相关的风险与农药接触。新生没有痴呆,男性比女性多报道农药接触(p < 0.0001)。个人(n = 572)的受教育年限(p < 0.01),但没有不同于其他年龄。大约500个人开发事件痴呆,344年,广告。性别、教育、APOE epsilon4状态和基线细微精神状态检查修改分数,Cox比例风险模型风险增加之间pesticide-exposed全因痴呆,个人风险比(人力资源)1.38和95%可信区间(CI)1.09 - -1.76,对于广告(HR 1.42, 95%可信区间1.06 - -1.91)。有机磷暴露(HR 1.53, 95%可信区间1.05 - -2.23)略高于风险与有机氯(HR 1.49, 95%可信区间0.99 - -2.24),这几乎是显著的。结论:农药暴露可能会增加年末痴呆和阿尔茨海默病的风险的生活。

著录项

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号