Organocatalytic Asymmetric Synthesis of β-Aryl-β-isocyano Esters

摘要

The asymmetric addition of malonates to in situ generated N-formylimines of aromatic aldehydes was achieved under phase-transfer catalysis using Cinchona alkaloids-derived quaternary ammonium salts. The resulting β-formamidomalonates have been efficiently converted into β-aryl-β-isocya-no esters. Their utility in the multicomponent Ugi re- action with chiral cyclic imines has been demonstrated.