Enantioselective Aza-Henry Reaction with Acyclic Guanidine- Thiourea Bifunctional Organocatalyst

摘要

A highly enantioselective aza-Henry reaction of imines with nitromethane was achieved with a reactive guanidine-thiourea bifunctional organocatalyst affording β-nitroamines with high enantio-selectivity (up to 96% ee). The diastereo- and enantioselective version of this reaction with nitroal-kanes also proceeded selectively (up to 99:1 dr with 99% ee).