Letter to the Editor

摘要

We read with great interest the review by Saxon and Turner entitled, "Estrogen receptor beta: the antimechanostat?" . In it, they propose that signaling through ER(J retards periosteal bone formation and suppresses gains in bone size and bone strength, and for these reasons they postulate that ER(beta) behaves as an "antimechanostaf . Based on animal and human data, there is considerable evidence, as indicated by the authors, that estrogen suppresses periosteal bone formation but stimulates endo-cortical bone formation. The real issue is whether this is due, as suggested by Saxon and Turner, to ER(beta) action on the periosteal surface vs. ERa action on the endocortical surface, or due to differential effects of estrogen acting via ERa on the periosteal vs. endocortical surfaces. We believe the latter possibility is much more likely and as such, have to disagree with the fundamental hypothesis of the review for several reasons.