Successful mobilization and engraftment of PBSCs derived from donor cord blood cells after a previous allogeneic RIC single unrelated cord blood transplantation.

摘要

We describe a successful salvage treatment with intensive chemotherapy and stem cell transplantation for a relapse of Hodgkin lymphoma (HL) after single umbilical cord blood transplantation with a reduced intensity-conditioning regimen (RIC). The originality of this observation is the source of cells for the second transplantation; the grafted cells were obtained by the mobilization in the blood of stem cells (PBSCs) originating from the cord blood unit (CBU) used for the previous transplantation.A 24-year-old patient was diagnosed with a nodular sclerosis classic HL (stage II Bb according to the Ann Arbor classification) in May 2007. A primary refractory disease was observed after 4 courses of adriamycin, bleomycin, vinblastine, and decarbazine (ABVD); 2 courses of mitoguazone, ifosfamide, vinorelbine, and etoposide plus rituximab (MINE-R); 2 courses of high-dose cytarabine (Ara-C), cisplatin, and dexamethasone (DHAP); and cervical irradiation (supplemental Table 1, available on the Blood Web site; see the Supplemental Materials link at the top of the online article).