NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation.

摘要

Distinct polymorphisms of NOD2/CARD15 (rs2066844 [SNP08], rs2066845 [SNP12], and rs2066847 [SNP13]) have influence on the incidence of Crohn disease (CD), a chronic inflammatory disorder of the gastrointestinal tract. Similar symptoms of CD and GVHD after allogeneic stem cell transplantation (allo-SCT) inspired Holler and coworkers to initiate a study that actually showed association of these polymorphisms and transplantation outcome. Subsequently some groups confirmed unfavorable association, whereas others did not. Because the impact of NOD2/CARD15 on SCT is still debatable, we initiated a retrospective multicenter study in pediatric patients (median age 9.8 years [0.2-21 years]) who received allo-SCT. The study was approved by the Goethe-University ethics committee (no. 294/05) and informed consent was obtained according to the Declaration of Helsinki. Genetic variants were analyzed in 567 donor-recipient pairs transplanted between 1996 and 2008. Of these, 446 were HLA-matched and 121 were mismatched.